https://video.igem.org/videos/watch/0e325df8-8873-4a07-bd0d-76c28b5091df Title: DermaSense: A living, air pollution-responsive moisturiser Description: Delhi’s annual PM2.5 has hovered near 100 µg/m³ since 2021, about twenty times the WHO guideline. Particulates and ozone drive reactive oxygen species that harm the skin. Conventional moisturisers use one fixed dose. DermaSense is a living alternative. We are engineering Staphylococcus epidermidis, a skin-commensal, so that a redox-sensitive regulator opens a synthetic operon under oxidative stress. The operon makes pulcherrimin, an antioxidant that also absorbs UV, together with xylolipid and lyso-ornithine lipid, biosurfactants that emulsify and hydrate at the barrier. We established proof of concept for lyso-ornithine lipid biosynthesis in E. coli, paving the way for its potential integration into a skin-associated microbial chassis. Our software integrates live air-quality data across the globe to estimate pollution-induced damage and potential protection offered by these molecules. Our vision is skincare that no longer sits on the skin but lives within it: responsive, self-regulating, and sustained by microbiome itself. Wiki | Official Page Thu, 29 Oct 2026 22:24:31 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/0e325df8-8873-4a07-bd0d-76c28b5091df All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.