https://video.igem.org/videos/watch/11224aeb-c7fe-411a-a949-9134329c8121 Title: HEAL Description: Worldwide pet population reached almost 1 billion, highlighting the importance of feline healthcare. Hair swallowed during grooming can accumulate and potentially cause gastrointestinal problems, while conventional hairball products mainly facilitate passage rather than degrade hair itself. HEAL explores a P1–Trx–TrxR enzyme system for hair degradation, alongside an exploratory α-ketoglutarate production module for potential intestinal support. Calcium alginate encapsulation and a bile-acid-responsive containment circuit address delivery and biosafety questions, complemented by a food-weighing prototype for feeding records. Separately, a bile-acid-responsive containment circuit tackles biosafety by linking bacterial growth to an bile-acid signal that is scarce in the environment. Integrating stakeholder feedback, in-vitro experiments, and modeling, HEAL advances research toward practical and responsible hairball management while identifying further validation needed before feline application. Wiki | Official Page Thu, 29 Oct 2026 22:24:32 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/11224aeb-c7fe-411a-a949-9134329c8121 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.