https://video.igem.org/videos/watch/1d0252dc-2f10-4e3b-8d68-ca329d6c71fb Title: dSyPhER: dynamic Synthetic Phosphorylation via Effector Response Description: This video introduces dSyPhER (Dynamic Synthetic Phosphorylation via Effector Response), a synthetic biology framework designed for real-time, cell-based disease diagnostics and monitoring. By utilizing engineered monocytes equipped with MESA-gated reporter circuits, dSyPhER enables targeted detection within disease microenvironments. Patient-derived monocytes are isolated, loaded with synthetic receptor constructs, and introduced into circulation. Upon homing to affected tissues, these engineered cells engage target surface biomarkers on diseased cells, triggering a synthetic signal cascade that produces a measurable reporter protein readout. Official Page Sat, 29 Aug 2026 17:16:25 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/1d0252dc-2f10-4e3b-8d68-ca329d6c71fb All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.