https://video.igem.org/videos/watch/2b86b823-841b-4a78-a58c-ffdb143de968 Title: RESTART: Rethinking Life After Organ Transplantation Description: RESTART begins with the problem: transplant patients depend on lifelong immunosuppressants, which leave them open to infections and repeated rejection episodes. We then share what patients and clinicians told us, and how their input shaped our goal of improving patients’ quality of life. Next, we introduce the RESTART cascade, a modular AND-gate synNotch circuit that produces IL-10 only when it recognizes both the transplanted organ (HLA-A2) and inflammation (VCAM-1). The video walks through our two-track cell line design, our lab work, and our results, including proof of principle for the full cascade. We also cover our modeling of the receptors and IL-10 diffusion. We close with the road toward a real therapy in regulatory T cells and our outreach on organ transplantation. Wiki | Official Page Thu, 29 Oct 2026 22:22:19 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/2b86b823-841b-4a78-a58c-ffdb143de968 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.