https://video.igem.org/videos/watch/30e49632-7fb4-42bd-b222-0c99e920a1f7 Title: A New Herbal Approach to Weight Loss: Functional Foods Targeting SULT Enzymes Description: This project targets human sulfotransferases (SULT2B1, SULT1E1, SULT2A1) involved in metabolic regulation. Using a fluorescence-based high-throughput screening platform, natural compounds are screened via molecular docking and validated for SULT inhibition. Synergistic inhibitor combinations are identified using Chou-Talalay analysis. A dual-enzyme biosynthesis system (UGT88D4 + UGD) is engineered in E. coli to produce bioactive flavonoid glycosides. The final formulation is tested in 3T3-L1 adipocyte differentiation models for reduced lipid accumulation and adipogenic gene expression. This work provides a functional food strategy for weight management. Official Page Sat, 29 Aug 2026 17:17:24 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/30e49632-7fb4-42bd-b222-0c99e920a1f7 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.