https://video.igem.org/videos/watch/33aec13d-e0fd-4ae4-810e-98dd8ecbab95 Title: dSyPhER; Dynamic Synthetic Phosphorylation via Effector Response Description: Diagnostics are episodic by construction: each test is a single observation, and between observations there is no information at all. dSyPhER closes that gap — an engineered cell that detects two disease markers simultaneously, computes an AND decision through a synthetic phosphorylation relay, rejects weak or transient signals with a tunable phosphatase threshold, and reports at the level of translation rather than transcription. Only the sensing layer is disease-specific, so retargeting means swapping a binding domain, not rebuilding the circuit. We demonstrate it on post-remission cancer relapse. The video covers our circuit design and engineering cycles, ODE modelling of the thresholding layer, stakeholder engagement, and our education and public engagement work. Wiki | Official Page Thu, 29 Oct 2026 21:21:37 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/33aec13d-e0fd-4ae4-810e-98dd8ecbab95 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.