https://video.igem.org/videos/watch/33e6c453-b8f2-4b21-b3f2-5061ccde3189 Title: AEGIS : Acid-rEsponsive self-assemblinG RGD-ES/KS peptides for tumor Invasion Suppression under weak acid conditions Description: We are developing an intelligent biomaterial that senses the acidic tumor microenvironment and self-assembles into micron-scale structures under tumor conditions. The system integrates an acid-responsive scaffold (ES) and an RGD peptide tag to achieve controlled assembly and tumor-targeted regulation. Through systematic optimization, RGD-6ES was identified as the optimal candidate, demonstrating the ability to inhibit lung cancer cell proliferation, migration, and adhesion in vitro. This biomaterial provides a promising strategy for developing localized postoperative implants to prevent tumor recurrence and invasion, with potential for further functional expansion. Wiki | Official Page Sat, 29 Aug 2026 17:17:20 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/33e6c453-b8f2-4b21-b3f2-5061ccde3189 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.