https://video.igem.org/videos/watch/4046ea51-4ed5-4f7a-b213-4045aecc6c31 Title: Missing Piece, Restored Hope: A New Era of Intelligent RNA Therapeutics Description: A missing room in a building can be rebuilt. But what happens when a region of the human chromosome disappears? Wolf-Hirschhorn syndrome (WHS), caused by a microdeletion on chromosome 4, results in insufficient expression of critical genes and severe developmental consequences. Inspired by the challenge of restoring what is lost, we developed a SINEUP-based therapeutic strategy to enhance protein production from remaining functional transcripts without altering the genome. By integrating artificial intelligence with programmable RNA design, we aim to create a scalable platform for treating microdeletion disorders and bring new hope to patients affected by haploinsufficiency. Wiki | Official Page Tue, 01 Sep 2026 16:54:54 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/4046ea51-4ed5-4f7a-b213-4045aecc6c31 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.