https://video.igem.org/videos/watch/47c92032-f61e-4836-8c7d-1c77e4d6bc75 Title: NEXO-For Those Who Go Far Description: Long-duration spaceflight costs astronauts up to 30% of their muscle mass — and current countermeasures can't keep up. NEXO is a three-layer GelMA microneedle patch that encapsulates engineered HEK-293T cells: a living factory beneath the skin. Its exosomes carry a guidance module that homes to skeletal muscle (BV2–Lamp2b targeting the BVES receptor), a cargo module actively loaded with Smad7 mRNA for dual blockade of the myostatin pathway, and a booster module raising yields 10–15-fold. One patch delivers weeks of continuous treatment — no cold chain, no repeated injections, no training burden. Built through five DBTL cycles, shaped by every voice we heard, NEXO grows medicine where it's needed. For those who go far, we guard every ounce of strength. Wiki | Official Page Thu, 29 Oct 2026 22:26:58 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/47c92032-f61e-4836-8c7d-1c77e4d6bc75 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.