https://video.igem.org/videos/watch/4aabbca4-e155-4caa-b482-8a5fe39bd31f Title: A New Approach to Herbal Weight Management: SULT Enzyme–Targeted Functional Foods Description: This project explores a synthetic-biology approach to functional food development by targeting sulfotransferase (SULT) enzymes associated with metabolic and hormonal pathways relevant to obesity. Through a complete Design–Build–Test–Learn cycle, we constructed and validated SULT2A1, SULT2B1, and SULT1E1 expression systems, screened small-molecule inhibitors using fluorescence-based enzyme assays, and identified promising competitive inhibition of SULT2B1. In parallel, we established a UGT88D4–UGD biosynthetic platform to convert flavonoid precursors into glycosides, offering a scalable route to optimize bioactive compounds. Together, our work connects enzyme-targeted screening, mechanistic validation, and microbial biosynthesis to support the future development of evidence-based functional foods. Wiki | Official Page Thu, 29 Oct 2026 21:20:31 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/4aabbca4-e155-4caa-b482-8a5fe39bd31f All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.