https://video.igem.org/videos/watch/5691596e-e72f-48aa-a9bf-457205298672 Title: Native-like programmablE cartilage Scaffold for Tissue repair (NEST) Description: Cartilage regeneration has long stood as one of the defining challenges of regenerative medicine: true repair requires rebuilding a load-bearing microenvironment where mechanics, anisotropic architecture, and biochemical signals act together. NEST, a native-like programmable engineered cartilage scaffold for tissue repair, uses synthetic biology to manufacture a biomimetic hydrogel that recreates this native logic from molecule to material. Its silk-elastin-like protein backbone is rationally designed to tune mechanical strength, crosslinking behavior, and tissue compatibility, while functional peptide modules introduce cartilage-oriented capabilities such as magnetic alignment, glycosaminoglycan retention, and inflammation-responsive cargo release. A modular ligation system enables these functions to be flexibly assembled and exchanged, tailoring the scaffold to patient-specific needs and diverse clinical conditions. By aligning molecular design with tissue-level function, NEST moves beyond replacing damaged cartilage toward restoring the biological principles that sustain it, envisioning biomaterials as dynamic microenvironments that help tissues recover their native form and function. Wiki | Official Page Thu, 29 Oct 2026 22:22:19 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/5691596e-e72f-48aa-a9bf-457205298672 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.