https://video.igem.org/videos/watch/6769d734-dfda-4234-891d-d845c6e06769 Title: FELIX：Feline Extermination Lipase (Spray) & RNAi Interference eXecution Platform Description: Feline infectious peritonitis (FIP), caused by mutated feline coronavirus (FCoV), remains a fatal disease with no cure. Current strategies lack an integrated solution covering environmental contamination, early intestinal infection, and established FIP. We introduce FELIX — a Anticoronavirus Nanoplatform for Noninvasive, Integrated Host & Environmental Viral Lysis & Antiviral Therapy . It is a unified EcNbased system designed to eliminate FCoV at every stage. Our threepronged strategy: Front 1 – Environmental disinfection: Engineered lipases EST29 and LIP29 degrade the viral lipid envelope, neutralizing viruses before host contact. Front 2 – Gut prophylaxis: EcN (E. coli Nissle 1917) continuously produces RNAi molecules targeting conserved FCoV sequences, clearing intestinal viruses before they mutate into FIPV. Front 3 – Therapeutic intervention: When FIP develops, the same EcN platform delivers RNAi therapeutics systemically to silence mutated viral genes, blocking replication and halting disease progression. Official Page Sat, 29 Aug 2026 17:17:30 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/6769d734-dfda-4234-891d-d845c6e06769 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.