https://video.igem.org/videos/watch/73e13c22-75b8-4ecb-98d8-0bf32c6ea320 Title: BMClick: one shell to click them all Description: This is a promotional video for BMClick, the 2026 iGEM project from team Vilnius-Lithuania. The project addresses a bottleneck in biotechnology: enzymes and nucleic acids do groundbreaking work, but outside the cell, their instability drains resources that could go toward discovery instead. The team's answer is a modular platform, built from engineered bacterial microcompartments (BMCs), that eases the work of handling biomolecules. BMClick uses a system where two components self-assemble into a hollow shell called the "Wiffle Ball," and a third protein seals its pores shut once cargo has been loaded inside. The animated part of the video walks through three ways the BMClick platform can be used. First, enzyme encapsulation: a SpyCatcher-SpyTag covalent bond anchors the enzyme inside the BMC's lumen, shielding it from denaturing conditions. Second, click chemistry: a non-canonical amino acid incorporated into the shell enables a Nobel Prize-winning bioorthogonal reaction for encapsulating or displaying virtually any molecule of interest, a step toward a therapeutic delivery platform. Third, functional surfaces: one of the SpyTag-containing building blocks of the BMC polymerizes into a proteinaceous film that can be dried, rehydrated, and renewed by rinsing away its top layer, presented as a sustainable foundation for spatially organized enzyme cascades, antimicrobial surfaces, or engineered bioconsortia. Three paths, one shell, one team: BMClick turns a natural bacterial box into a modular platform for synthetic biology. Wiki | Official Page Tue, 01 Sep 2026 16:53:21 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/73e13c22-75b8-4ecb-98d8-0bf32c6ea320 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.