https://video.igem.org/videos/watch/7bfbd077-8d10-4d57-a47a-457aefd778c6 PerioGuard — an engineered probiotic and a porous coating, designed to bring regenerative signals closer to the tissue that needs them. This overview follows the project's two-part design. The problem. Periodontitis does more than inflame the gums: it damages the tissues and the alveolar bone that hold teeth in place. Stopping the damage matters, but rebuilding what was lost is the harder problem. The design. A single molecule, 2FA, takes on two separate roles. Living module. Inside engineered E. coli Nissle 1917 (EcN), 2FA is converted to xanthine. A HucR-responsive circuit then controls expression of CsgA–AMG, and CsgA helps bring AMG outside the cell, where it can act on periodontal tissue., Material module. Separately, 2FA and CA self-assemble into PNAC (porous nucleoside-based adsorptive coating), a hydrogen-bonded framework that associates with the EcN surface, strengthening the material–bacterium association and reducing early phagocytic clearance., Where they meet. PNAC coats engineered EcN, combining protein delivery with a protective material interface — a living-material system designed to act locally at the periodontal site. Team SCU-WestChina · iGEM 2026 https://2026.igem.wiki/scu-westchina Tue, 20 Oct 2026 02:54:09 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/7bfbd077-8d10-4d57-a47a-457aefd778c6 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.