https://video.igem.org/videos/watch/7c4de0b3-c57f-44e0-9070-0334cf759a2a Title: SpliceLogic: Engineering RNA Trans-Splicing for Precision Genetic Therapeutics Description: NTU Singapore iGEM Team SpliceLogic introduces a revolutionary and universal RNA writing technology designed to transform the future of genetic medicine by moving beyond permanent DNA editing. Current gene-editing methods carry irreversible off-target risks, while conventional RNA-based approaches remain limited by single-base edits or inefficient natural splicing machinery. To solve this, Team SpliceLogic has engineered modular, dual-input logic gates that seamlessly integrate two core innovations: XPERT, which recruits natural enzymes to precisely disable disease-causing splice anchors and stall pathological pathways, and CRAFT, which uses specialized Cas effectors to tether therapeutic payloads exactly where they are needed and overcome traditional kinetic bottlenecks. By combining these mechanisms into a unified toolkit, the project provides a safe, temporary, and programmable solution to combat complex genetic disorders. Official Page Tue, 01 Sep 2026 16:54:34 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/7c4de0b3-c57f-44e0-9070-0334cf759a2a All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.