https://video.igem.org/videos/watch/868127a8-c5eb-43b3-b13c-8a18e55e11ca Title: Synthetic Biology Dressing for Diabetic Foot Healing Description: Every 20 seconds, one person worldwide faces amputation due to diabetic foot ulcers. High glucose damages nerves and blood vessels, causing chronic wound infection and non-healing, affecting over 10 million patients in China and 537 million diabetics globally. Powered by synthetic biology, team LUT-CHINA 2026 presents an innovative wound healing solution. We constructed engineered E. coli cell factories to produce high-purity, batch-consistent lobetyolin and calycosin-7-glucoside, eliminating the component fluctuation of traditional plant extraction. The dual active ingredients synergistically promote angiogenesis, accelerate epithelial growth, and exert anti-inflammatory and antioxidant effects, targeting the root causes of refractory diabetic foot wounds. We further developed a four-layer precision dressing loaded with the dual molecules: a soft silicone layer to prevent adhesion and reduce secondary injury; a self-assembled hydrogel layer for directional drug release; an alginate layer to absorb exudate and trap bacteria; an outer PU membrane for waterproofing and balanced breathability. From biosynthesis to product design, we redefine chronic wound healing with synthetic biology. Official Page Tue, 01 Sep 2026 16:54:06 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/868127a8-c5eb-43b3-b13c-8a18e55e11ca All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.