https://video.igem.org/videos/watch/8c80b884-395c-46d9-91c2-e433460d5cb5 Title: FibroSwitch: Reversing Liver Fibrosis with a Baicalein-Inducible Smart Vector Description: The HKBU iGEM 2026 team presents FibroSwitch, an innovative herbal-inducible gene therapy designed to reverse liver fibrosis by delivering the GATA4 transcription factor under the precise control of a synthetic pARE promoter triggered by the traditional Chinese medicine compound Baicalein. This presentation guides you through our engineering journey, detailing the constitutive validation of GATA4's anti-fibrotic effects in Phase 1, and the development of our lentiviral inducible switch in Phase 2. We explore the fascinating biological conflict uncovered in our RNA results, our hypotheses for the circuit's unexpected behavior, and our future redesign strategies. Finally, we highlight our nominations for Best Measurement, Best Education, and Best Integrated Human Practices, showcasing how our EAST framework and insights from global experts shaped a safer, more accessible translational roadmap. Wiki | Official Page Thu, 29 Oct 2026 21:22:07 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/8c80b884-395c-46d9-91c2-e433460d5cb5 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.