https://video.igem.org/videos/watch/a0688de7-3091-4056-a2d3-46e54c8070fc Title: Ubik: Programming Degradation with AI-Designed Ubiquitin Codes Description: Our project promotional video draws inspiration from Philip K. Dick’s sci-fi classic Ubik, using its mythical anti-aging spray as a metaphor for the body’s own ubiquitin-proteasome system (UPS). We briefly walk through the natural UPS mechanism and the inherent limitations of native E3 ubiquitin ligases, then introduce our AI-powered solution—the Ubiquitin Code Factory (Ubik). Ubik operates through two core modules—UbiR, which drives E3 recruitment, and UbiT, which governs target-protein specificity with high precision. Finally, mapping our designed amino-acid sequence to interesting music, we showcase the key developmental milestones for targeted protein degradation (TPD) made possible by our AI-driven research pipeline. Official Page Tue, 01 Sep 2026 16:54:35 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/a0688de7-3091-4056-a2d3-46e54c8070fc All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.