https://video.igem.org/videos/watch/c090e05a-730d-446f-912f-07065c6fd685 Title: AKGut: engineering E. coli Nissle 1917 to produce alpha-ketoglutarate in the gut Description: In this promotion video, the AKGut project is briefly defined and outlined. The intestinal barrier weakens with age in worms, flies, fish, rodents and primates, and its failure tracks mortality. In 2014, eight millimolar alpha-ketoglutarate raised the average lifespan of C. elegans by forty-seven percent. But in pigs, only about four percent of an oral dose reached the bloodstream. AKGut is engineering E. coli Nissle 1917, a probiotic in medical use for a century, to produce alpha-ketoglutarate in the gut rather than deliver it there. We are asking four questions: does the strain produce it, is it available outside the cell, does it get inside the worm, and does the worm live longer. Wiki | Official Page Tue, 01 Sep 2026 16:55:05 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/c090e05a-730d-446f-912f-07065c6fd685 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.