https://video.igem.org/videos/watch/c5659d10-959f-4356-913a-a85d8285a7c9 Title: A Hydrogel-Probiotic Platform for Microbiome Restoration and Barrier Repair in Atopic Dermatitis Description: This video introduces FROST, an engineered living therapeutic designed to treat Atopic Dermatitis (AD) at its biological root — not just its symptoms. You'll see how FROST combines a smart hydrogel with a reprogrammed probiotic, Lactiplantibacillus plantarum, that activates only inside inflamed skin lesions. Guided by an adhesin-based targeting system, the bacteria anchor to the site of inflammation, outcompete pathogenic S. aureus, and deliver anti-inflammatory siRNA directly into skin cells — silencing the NF-κB and STAT6 pathways responsible for itch, redness, and barrier breakdown. The video also walks through FROST's built-in biosafety architecture: a temperature-sensing RNA thermometer and an H₂O₂-triggered genetic kill switch that ensure the bacteria survive only within the lesion and self-destruct if they leave it. FROST represents a new category of medicine — living, responsive, and self-limiting therapeutics that know where to go, when to act, and when to stop. This is our vision for the future of dermatology: from managing symptoms to true skin restoration. Wiki | Official Page Sat, 29 Aug 2026 17:17:24 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/c5659d10-959f-4356-913a-a85d8285a7c9 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.