https://video.igem.org/videos/watch/ccf1e84a-e6a6-4ce4-9296-012665eb86ba Most commercial gene synthesis providers will not produce highly repetitive sequences under standard pricing. Repetitive genes fail the sequence-complexity filters that vendors run before a synthesis order is accepted, so the order is either rejected outright or pushed into a bespoke, high-cost, long-lead-time service. This is not an arbitrary policy. The repetitive sequences create problems with synthesis as the DNA complex and mis- or self-anneal. For iGEM teams working with repetitive sequences like Elastin-like polypeptides, synthesis is a critical bottleneck. This creates a significant disadvantage since major iGEM sponsors like IDT and GenScript restrict synthesis of repetitive DNA. We have designed, built and validated a browser-based designer "MOSAIC Designer" that generates synthesis-ready library sequences, and that ships with our tested MOSAIC library genes. Check it out on our wiki Thu, 15 Oct 2026 15:52:45 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/ccf1e84a-e6a6-4ce4-9296-012665eb86ba All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.