https://video.igem.org/videos/watch/da0d440f-2e06-44a5-b654-275fcde49e76 Title: Cardivit: Engineered E. coli for Salvianic acid A Production and Cardiovascular Protection Description: Salvianic acid A (SAA) is a major bioactive compound derived from Salvia miltiorrhiza, exhibiting antioxidant, anti-inflammatory, and cardiovascular protective properties. It has significant potential in cardiovascular disease prevention and the development of natural bioactive compounds. However, current SAA production mainly relies on extraction from plants, which is limited by long growth cycles, low yields, and strong dependence on environmental conditions, restricting its large-scale production and application. In this project, synthetic biology approaches are employed to construct an engineered microbial platform for efficient, stable, and sustainable SAA production. By introducing key genes involved in the SAA biosynthetic pathway and optimizing endogenous metabolic pathways, the supply of essential precursors is enhanced to improve SAA biosynthesis efficiency. Furthermore, to ensure the safety of engineered microorganisms, a dual biocontainment system based on anaerobic environment-responsive regulation and arabinose-induced control is designed, enabling functional maintenance in the target environment while allowing safe elimination under non-target conditions or specific triggers. By integrating synthetic biology with natural product biomanufacturing, this project aims to establish a green, efficient, and controllable SAA production platform, providing a novel strategy for the modernization and sustainable development of traditional medicinal compounds. Wiki | Official Page Tue, 01 Sep 2026 16:53:22 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/da0d440f-2e06-44a5-b654-275fcde49e76 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.