https://video.igem.org/videos/watch/dc9e5bad-2121-4989-9d6d-f157f287d6e8 Title: PB-Shock Description: Our project aims at developing a living, locally active oral biotherapeutic platform for treating colorectal cancer. Rather than infusing cytotoxic agents throughout the entire body, our system leverages an engineered, food-grade probiotic strain Lactobacillus casei ATCC 393 to produce and secrete the human cytokine IL-37. By modifying the bacterial surface with a cadherin-targeting peptide, it specifically targets colorectal cancer cells and intended to promote preferential bacterial localisation and retention at tumour sites, enabling local IL-37 secretion. We hypothesise that this local delivery could achieve concentrations sufficient to induce antitumour effects while keeping exposure in healthy tissues below an effective level. Through continuous engagement with stakeholders, we determined how our project serves the public and evaluated the ethical, safety, and societal implications of our biotherapeutic platform. Beyond that, we designed innovative educational and outreach activities to open a two-way dialogue with new communities regarding synthetic biology and public health. Wiki | Official Page Thu, 29 Oct 2026 22:26:06 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/dc9e5bad-2121-4989-9d6d-f157f287d6e8 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.