https://video.igem.org/videos/watch/dca7f5b6-075e-46f1-97a3-79806bfddffa Title: FIV-UR: Sweet Science, Smarter Therapy [English] Description: Urinary tract infections (UTIs) are one of the most common bacterial infections, yet treatment increasingly faces challenges from antibiotic resistance. We are engineering a bacterial sensing system that detects the chemical environment of a UTI and responds by producing a targeted anti-inflammatory compound. During a UTI, the infecting bacteria alter local levels of nutrients like phosphate and magnesium. Our system exploits this: when those nutrient levels drop, natural bacterial signaling pathways switch on a gene that produces an enzyme called YjiC. This enzyme modifies fisetin, a plant-derived anti-inflammatory molecule, into a more soluble, bioavailable form that can help reduce the inflammation and tissue damage caused by infection. Rather than flooding the body with a drug, our approach aims to produce the therapeutic only where and when infection is present. Wiki | Official Page Sat, 29 Aug 2026 17:16:25 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/dca7f5b6-075e-46f1-97a3-79806bfddffa All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.