https://video.igem.org/videos/watch/ddf85282-71f2-4274-8444-10cce28c2389 Title: X-bat——The Monkey King Subdues the Demon: Engineered Bacteria vs. Pancreatic Cancer Description: X-bat: The Monkey King Subdues the Demon Pancreatic cancer is called the "King of Cancers" — five-year survival under 12%, hidden in low-oxygen tissue, walled behind a microenvironment immune cells cannot enter. We told that story the way our ancestors would have: as a legend, cut from red paper. In our film, the demon is pancreatic ductal adenocarcinoma. The mountain cave is the hypoxic, immune-cold tumor. The soldiers who fail at its gates are conventional therapy. And the Monkey King is Bifidobacterium longum — an anaerobic gut bacterium we engineered into a tumor-seeking living therapeutic. How X-bat works: 1. Build — engineered B. longum chassis 2. Target — anaerobic chemotaxis drives it to the tumor's hypoxic core 3. Colonize — natural internalization into tumor cells 4. Expose — Galectin-triggered xenophagy loads bacterial peptides onto MHC-II 5. Ignite — CD4⁺ T cell activation turns a cold tumor hot Safety by design: O₂-gated expression, GRAS chassis, and a kill switch. Every frame is original artwork, hand-designed in the Chinese paper-cut tradition. Sun Wukong is a public-domain literary character; no existing film or television design was reproduced. 🔗 Wiki: https://2026.igem.wiki/izju-china/ Team: iZJU-China 2026 Pancreatic cancer, synthetic biology, engineered probiotics, Bifidobacterium longum, tumor immunotherapy, cold tumor, xenophagy, paper-cut animation Wiki | Official Page Tue, 01 Sep 2026 16:54:35 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/ddf85282-71f2-4274-8444-10cce28c2389 All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.