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        <title>NFLSHS-CHINA: Croteen: When a Hundred and Fifty Thousand Flowers are replaced with bacteria (2026) - Project Promotion</title>
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        <description>Title: Croteen: When a Hundred and Fifty Thousand Flowers are replaced with bacteria Description: Saffron — the world's most expensive spice — yields crocetin, a powerful natural antioxidant and bioactive compound with tremendous therapeutic potential. But extracting it from saffron is costly, labor-intensive, and limited by harvest yields—each gram of saffron demands the hand-picking of approximately 150,000 Crocus sativus flowers. Our project, Croteen, asks what if a few bottles of bacteria could do the work of 150,000 flowers. By engineering E. coli with an eight-enzyme pathway, we turn the microbe into a crocetin micro-factory, producing this invaluable compound through scalable fermentation instead of labor-intensive cultivation. With large-scale production confirmed, we launched crocetin essential oil and crocetin capsules, both built around its potential to relieve anxiety. And when our process drives costs down a hundredfold or even a thousandfold, what was once “Red Gold” will become accessible to all. Official Page</description>
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