https://video.igem.org/videos/watch/f1089c11-09db-4ac0-a569-011e5df01d0b Title: FLAME Description: FLAME (Functional Layered Anti-tumor Microbial Executor) is a research-stage engineered probiotic system designed for localized colorectal cancer therapy. By integrating tumor-associated signals—including hypoxia, high lactate, and quorum sensing—FLAME uses layered control to activate GSDMD-N specifically at the tumor site, inducing pyroptosis while limiting effects on healthy tissue. This video presents the design concept, proposed mechanism, local immune response, safety strategy, and experimental validation of the FLAME project. Official Page Tue, 01 Sep 2026 16:55:03 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/videos/watch/f1089c11-09db-4ac0-a569-011e5df01d0b All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder.