Main leytonlin channel https://video.igem.org/c/leytonlin_channel/videos Wed, 21 Oct 2026 02:50:54 GMT https://validator.w3.org/feed/docs/rss2.html PeerTube - https://video.igem.org Main leytonlin channel https://video.igem.org/client/assets/images/icons/icon-1500x1500.png https://video.igem.org/c/leytonlin_channel/videos All rights reserved, unless otherwise specified in the terms specified at https://video.igem.org/about and potential licenses granted by each content's rightholder. https://video.igem.org/feeds/podcast/videos.xml?videoChannelId=4123 <![CDATA[UChicago: Genelock Mechanism (2026) [English]]]> https://video.igem.org/w/ffdviX4mASx1m5GcsD7K8F https://video.igem.org/w/ffdviX4mASx1m5GcsD7K8F Tue, 20 Oct 2026 14:45:34 GMT This video goes over the mechanism of our Genelock construct, where a DNA-binding domain binds to a target DNA sequence. Lots of other constructs localize to this DNA sequence, and start to oligomerize together with our Oligomerization Domain (also located on the construct). Our synthetically-designed Intrinsically disordered domain causes the proteins to clump and aggregate together, forming a liquid liquid phase condensate, blocking the polymerase from accessing any DNA.

Credit goes to Jacob Rothman the movie. Our wiki link is here: https://2026.igem.wiki/uchicago/index.html

]]> Main leytonlin channel Science & Technology nonadult UChicago: Genelock Mechanism (2026) [English] This video goes over the mechanism of our Genelock construct, where a DNA-binding domain binds to a target DNA sequence. Lots of other constructs localize to this DNA sequence, and start to oligomerize together with our Oligomerization Domain (als...